Budapest Post

Cum Deo pro Patria et Libertate
Budapest, Europe and world news

Pfizer Jab Provides Less Immunity To Omicron Than Other Variants

Pfizer Jab Provides Less Immunity To Omicron Than Other Variants

Researchers at the Africa Health Research Institute in Durban, South Africa, found omicron resulted in about a 40-fold reduction in levels of neutralizing antibodies produced by people who had received two doses of the Pfizer-BioNTech SE shot.

Pfizer Inc.'s vaccine provides less immunity to the omicron variant than to other major versions of Covid-19, according to laboratory experiments that still indicated a third dose may help stop the highly mutated strain.

Researchers at the Africa Health Research Institute in Durban, South Africa, found omicron resulted in about a 40-fold reduction in levels of neutralizing antibodies produced by people who had received two doses of the Pfizer-BioNTech SE shot, compared with the strain detected in China almost two years ago.

The loss of immune protection is "robust, but not complete," Alex Sigal, head of research at the laboratory, said in an online presentation of the first reported experiments gauging the effectiveness of the vaccine against the new variant.

"There will be more breakthrough" of vaccine-induced immunity, Sigal said. "A good booster probably would decrease your chance of infection, especially severe infection leading to more severe disease. People who haven't had a booster should get one, and people who have been previously infected should be vaccinated."

Representatives for Pfizer and BioNTech, makers of the first Covid vaccine cleared in the U.S., didn't immediately respond to a request for comment. The study may add to the debate over whether tweaked, omicron-targeted vaccines will be needed soon to continue effectively fighting the pandemic. Moderna Inc. President Stephen Hoge has said there's a risk that existing vaccines will be less effective against the strain, although U.S. medical adviser Anthony Fauci said the severity of illness caused by the variant may be limited.

Omicron's rapid spread in South Africa has raised concern that the immune protection from vaccination or a previous bout of Covid-19 may be insufficient to stop reinfections or stem a fresh wave of cases and hospitalizations. The World Health Organization has warned omicron could fuel surges with "severe consequences" amid signs that it makes the coronavirus more transmissible.

Cautious Optimism


Still, the jump in cases in South Africa following omicron's emergence hasn't overwhelmed hospitals so far, prompting some cautious optimism that the new strain may cause mostly mild illness.

Since South Africa announced the discovery of omicron on Nov. 25, about 450 researchers globally have been working to isolate the variant from patient specimens, grow it in labs, verify its genomic sequence, and establish methods to test it in blood-plasma samples, according to the WHO.

The work in Sigal's lab involved testing 14 blood plasma samples collected from a dozen people who had been given a second Pfizer-BioNTech shot about a month earlier to gauge the concentration of antibodies needed to neutralize, or block, the virus. Levels of neutralizing antibodies against omicron were notably higher in a subset of participants who had a bout of Covid about a year earlier, Sigal said.

That's "promising," said John Wherry, director of the institute for immunology at the University of Pennsylvania's Perelman School of Medicine. It likely means an additional dose of the currently available vaccines would boost levels of neutralizing antibodies to omicron, though more data are needed to confirm that, he said.

The results are preliminary and exact levels of immune escape may change, Sigal said. The results, along with those from other labs studying the strain, will help determine whether existing Covid vaccines need to be altered to protect against omicron.

Sigal's laboratory was the first to isolate the beta variant, a strain of the coronavirus that was identified in South Africa in late 2020. He noted that omicron escapes antibody neutralization more readily than beta, which had been considered the most immune evasive of the variants of concern detected previously.

AI Disclaimer: An advanced artificial intelligence (AI) system generated the content of this page on its own. This innovative technology conducts extensive research from a variety of reliable sources, performs rigorous fact-checking and verification, cleans up and balances biased or manipulated content, and presents a minimal factual summary that is just enough yet essential for you to function as an informed and educated citizen. Please keep in mind, however, that this system is an evolving technology, and as a result, the article may contain accidental inaccuracies or errors. We urge you to help us improve our site by reporting any inaccuracies you find using the "Contact Us" link at the bottom of this page. Your helpful feedback helps us improve our system and deliver more precise content. When you find an article of interest here, please look for the full and extensive coverage of this topic in traditional news sources, as they are written by professional journalists that we try to support, not replace. We appreciate your understanding and assistance.
Newsletter

Related Articles

0:00
0:00
Close
Vatican hosts first Catholic LGBTQ pilgrimage
Apple Unveils iPhone 17 Series, iPhone Air, Apple Watch 11 and More at 'Awe Dropping' Event
France joins Eurozone’s ‘periphery’ as turmoil deepens, say investors
France Faces New Political Crisis, again, as Prime Minister Bayrou Pushed Out
Nayib Bukele Points Out Belgian Hypocrisy as Brussels Considers Sending Army into the Streets
France, at an Impasse, Heads Toward Another Government Collapse
The Country That Got Too Rich? Public Spending Dominates Norway Election
EU Proposes Phasing Out Russian Oil and Gas by End of 2027 to End Energy Dependence
More Than 150,000 Followers for a Fictional Character: The New Influencers Are AI Creations
EU Prepares for War
Trump Threatens Retaliatory Tariffs After EU Imposes €2.95 Billion Fine on Google
Tesla Board Proposes Unprecedented One-Trillion-Dollar Performance Package for Elon Musk
Gold Could Reach Nearly $5,000 if Fed Independence Is Undermined, Goldman Sachs Warns
Uruguay, Colombia and Paraguay Secure Places at 2026 World Cup
Trump Administration Advances Plans to Rebrand Pentagon as Department of War Instead of the Fake Term Department of Defense
Big Tech Executives Laud Trump at White House Dinner, Unveil Massive U.S. Investments
Tether Expands into Gold Sector with Profit-Driven Diversification
‘Looks Like a Wig’: Online Users Express Concern Over Kate Middleton
Florida’s Vaccine Revolution: DeSantis Declares War on Mandates
Trump’s New War – and the ‘Drug Tyrant’ Fearing Invasion: ‘1,200 Missiles Aimed at Us’
"The Situation Has Never Been This Bad": The Fall of PepsiCo
At the Parade in China: Laser Weapons, 'Eagle Strike,' and a Missile Capable of 'Striking Anywhere in the World'
The Fashion Designer Who Became an Italian Symbol: Giorgio Armani Has Died at 91
Putin Celebrates ‘Unprecedentedly High’ Ties with China as Gazprom Seals Power of Siberia-2 Deal
China Unveils New Weapons in Grand Military Parade as Xi Hosts Putin and Kim
Rapper Cardi B Cleared of Liability in Los Angeles Civil Assault Trial
Google Avoids Break-Up in U.S. Antitrust Case as Stocks Rise
Couple celebrates 80th wedding anniversary at assisted living facility in Lancaster
Information Warfare in the Age of AI: How Language Models Become Targets and Tools
The White House on LinkedIn Has Changed Their Profile Picture to Donald Trump
"Insulted the Prophet Muhammad": Woman Burned Alive by Angry Mob in Niger State, Nigeria
Trump Responds to Death Rumors – Announces 'Missile City'
Druzhba Pipeline Incident Sparks Geopolitical Tensions
Cost of Opposition Leader Péter Magyar's Economic Plan Revealed
Germany in Turmoil: Ukrainian Teenage Girl Pushed to Death by Illegal Iraqi Migrant
United Krack down on human rights: Graham Linehan Arrested at Heathrow Over Three X Posts, Hospitalised, Released on Bail with Posting Ban
Asian and Middle Eastern Investors Avoid US Markets
Ray Dalio Warns of US Shift to Autocracy
Eurozone Inflation Rises to 2.1% in August
Russia and China Sign New Gas Pipeline Deal
Von der Leyen's Plane Hit by Suspected Russian GPS Interference in an Incident Believed to Be Caused by Russia or by Pro-Peace or by Anti-Corruption European Activists
China's Robotics Industry Fuels Export Surge
Suntory Chairman Resigns After Police Probe
Gold Price Hits New All-Time Record
UK Fintechs Explore Buying US Banks
Greece Suspends 5% of Schools as Birth Rate Drops
Apollo to Launch $5 Billion Sports Investment Vehicle
Bolsonaro Trial Nears Close Amid US-Brazil Tension
European Banks Push for Lower Cross-Border Barriers
Poland's Offshore Wind Sector Attracts Investors
×