Anti-Covid Drug Trial Shows "Robust Efficacy": AstraZeneca
The AstraZeneca Covid drug AZD7442, made from a combination of two antibodies, has been undergoing final stage clinical trials to assess its safety and efficacy.
Pharmaceutical giant AstraZeneca on Thursday announced that clinical trials of an antibody-based COVID-19 drug had shown robust efficacy and long-term prevention.
The Anglo-Swedish laboratory follows in the footsteps of US firms Merck and Pfizer, which announced in October and early November respectively that they had developed drugs that could prevent severe forms of the disease, and that could be taken at the first sign of symptoms.
The AstraZeneca drug AZD7442, made from a combination of two antibodies, has been undergoing final stage clinical trials to assess its safety and efficacy.
A six-month follow-up trial "showed robust efficacy from a one-time intramuscular (IM) dose of the long-acting antibody (LAAB) combination", it said in a statement.
One 300mg IM dose reduced the risk of developing symptomatic COVID-19 compared to placebo by 83 percent, it added.
More than 75 per cent of participants had co-morbidities that put them at high risk for severe COVID-19 if they were to become infected, but no severe cases were recorded.
Another trial to test its efficacy in treating those already suffering from "mild to moderate" Covid symptoms showed that one 600mg IM dose reduced the risk of developing severe illness or death by 88 percent.
"These compelling results give me confidence that this long-acting antibody combination can provide my vulnerable patients with the long-lasting protection they urgently need to finally return to their everyday lives," said Hugh Montgomery, professor of intensive care medicine at University College London.
"Importantly, six months of protection was maintained despite the surge of the Delta variant among these high-risk participants who may not respond adequately to vaccination."
AstraZeneca said the full results of both trials would be submitted for publication to a peer-reviewed medical journal.
It has already submitted an application to US regulators for approval of the drug to treat COVID-19.
AstraZeneca's separate Covid vaccine, developed with the University of Oxford, helped enable Britain's speedy Covid vaccination drive after it was approved in December 2020.
The Anglo-Swedish laboratory follows in the footsteps of US firms Merck and Pfizer, which announced in October and early November respectively that they had developed drugs that could prevent severe forms of the disease, and that could be taken at the first sign of symptoms.
The AstraZeneca drug AZD7442, made from a combination of two antibodies, has been undergoing final stage clinical trials to assess its safety and efficacy.
A six-month follow-up trial "showed robust efficacy from a one-time intramuscular (IM) dose of the long-acting antibody (LAAB) combination", it said in a statement.
One 300mg IM dose reduced the risk of developing symptomatic COVID-19 compared to placebo by 83 percent, it added.
More than 75 per cent of participants had co-morbidities that put them at high risk for severe COVID-19 if they were to become infected, but no severe cases were recorded.
Another trial to test its efficacy in treating those already suffering from "mild to moderate" Covid symptoms showed that one 600mg IM dose reduced the risk of developing severe illness or death by 88 percent.
"These compelling results give me confidence that this long-acting antibody combination can provide my vulnerable patients with the long-lasting protection they urgently need to finally return to their everyday lives," said Hugh Montgomery, professor of intensive care medicine at University College London.
"Importantly, six months of protection was maintained despite the surge of the Delta variant among these high-risk participants who may not respond adequately to vaccination."
AstraZeneca said the full results of both trials would be submitted for publication to a peer-reviewed medical journal.
It has already submitted an application to US regulators for approval of the drug to treat COVID-19.
AstraZeneca's separate Covid vaccine, developed with the University of Oxford, helped enable Britain's speedy Covid vaccination drive after it was approved in December 2020.
AI Disclaimer: An advanced artificial intelligence (AI) system generated the content of this page on its own. This innovative technology conducts extensive research from a variety of reliable sources, performs rigorous fact-checking and verification, cleans up and balances biased or manipulated content, and presents a minimal factual summary that is just enough yet essential for you to function as an informed and educated citizen. Please keep in mind, however, that this system is an evolving technology, and as a result, the article may contain accidental inaccuracies or errors. We urge you to help us improve our site by reporting any inaccuracies you find using the "Contact Us" link at the bottom of this page. Your helpful feedback helps us improve our system and deliver more precise content. When you find an article of interest here, please look for the full and extensive coverage of this topic in traditional news sources, as they are written by professional journalists that we try to support, not replace. We appreciate your understanding and assistance.
