Budapest Post

Cum Deo pro Patria et Libertate
Budapest, Europe and world news

30-Year-Old Woman Whose HIV Vanished Gives Hope For AIDS Cure

30-Year-Old Woman Whose HIV Vanished Gives Hope For AIDS Cure

Progress against AIDS over the past two decades has inspired a commitment by United Nations member states to end the epidemic by 2030.

All signs of HIV have disappeared in a young woman who was diagnosed with the virus that causes AIDS in 2013, researchers said, raising hopes that she may be one of a handful of people worldwide who has permanently fought off the infection.

The 30-year-old mother, originally from the city of Esperanza in Argentina, has the clinical features of an HIV "elite controller," meaning her infection has been undetectable for years. It didn't reemerge even after she stopped taking powerful drugs to treat it, which is what normally happens, researchers said in a studyslated for publication in the Annals of Internal Medicine.

The virus also doesn't appear to have integrated into her DNA, creating what is known as a provirus, and extensive testing failed to turn it up anywhere. It's possible that she has experienced what is known as a "sterilizing cure," meaning she is no longer carrying a replicating form of the virus, they said.

No Answers


How it happened is a mystery. At least two other HIV patients have also been deemed cured, but both underwent extensive treatment for blood cancer that involved stem cell transplants. The researchers offered no answers as to how the young mother eradicated the virus, but her existence suggests it is possible.

The virus "was not detected in an elite controller despite analysis of massive numbers of cells from blood and tissues, suggesting that this patient may have naturally achieved a sterilizing cure of HIV-1 infection," said researchers led by Xu Yu at Boston's Ragon Institute and Natalia Laufer from the Institute of Biomedical Research in Retrovirus and AIDS in Buenos Aires. "These observations raise the possibility that a sterilizing cure may be an extremely rare but possible outcome of HIV-1 infection."

Doctors have tried unsuccessfully for decades to eradicate the virus within patients. While combination drug therapies can suppress it so it's no longer detectable, the vast majority of patients still have a reservoir that's reactivated after treatment stops. Finding another person who's virus-free raises the hope for other ways to wipe out the reservoir and cure more people.

It's possible the patient's initial immune response to HIV led to an abortive infection or that her immune system became better at recognizing and destroying it over time, leaving only remnants of HIV behind, said co-author Sharon Lewin, director of the Peter Doherty Institute for Infection and Immunity at the University of Melbourne.

"People are excited about it because it's sort of another pathway to a cure," Lewin said in an interview Wednesday. "You can eventually get rid of intact virus and you're just left with these footprints of the virus."

About 1% of Caucasian people living with HIV develop control over the infection. It's possible a subset may be cured, meaning they no longer have any replication-competent HIV, said Lewin, who is studying the genetic details of what constitutes a cure.

'Berlin Patient'


The researchers said the Argentinian woman, whose partner died of AIDS in July 2017, resembles the "Berlin patient." That man, Timothy Brown, developed a probable sterilizing cure of HIV after undergoing a stem cell transplant to treat acute myeloid leukemia almost 15 years ago.

Since the beginning of the AIDS epidemic, almost 80 million people have been infected with HIV and 36.3 million people have died from complications of the viral illness. Worldwide, an estimated 37.7 million people were living with HIV in 2020.

Progress against AIDS over the past two decades has inspired a commitment by United Nations member states to end the epidemic by 2030. The number of people newly infected with HIV fell to 1.5 million worldwide in 2020, from 3 million in 1997.

AI Disclaimer: An advanced artificial intelligence (AI) system generated the content of this page on its own. This innovative technology conducts extensive research from a variety of reliable sources, performs rigorous fact-checking and verification, cleans up and balances biased or manipulated content, and presents a minimal factual summary that is just enough yet essential for you to function as an informed and educated citizen. Please keep in mind, however, that this system is an evolving technology, and as a result, the article may contain accidental inaccuracies or errors. We urge you to help us improve our site by reporting any inaccuracies you find using the "Contact Us" link at the bottom of this page. Your helpful feedback helps us improve our system and deliver more precise content. When you find an article of interest here, please look for the full and extensive coverage of this topic in traditional news sources, as they are written by professional journalists that we try to support, not replace. We appreciate your understanding and assistance.
Newsletter

Related Articles

0:00
0:00
Close
Severe Heatwave Claims 2,300 Lives Across Europe
Declining Beer Consumption Signals Cultural Shift in Germany
Emails Leaked: How Passenger Luggage Became a Side Income for Airport Workers
Polish MEP: “Dear Leftists - China is laughing at you, Russia is laughing, India is laughing”
Western Europe Records Hottest June on Record
BRICS Expands Membership with Indonesia and Ten New Partner Countries
Elon Musk Founds a Party Following a Poll on X: "You Wanted It – You Got It!"
China’s Central Bank Consults European Peers on Low-Rate Strategies
France Requests Airlines to Cut Flights at Paris Airports Amid Planned Air Traffic Controller Strike
Poland Implements Border Checks Amid Growing Migration Tensions
Emirates Airline Expands Market Share with New $20 Million Campaign
Amazon Reaches Milestone with Deployment of One Millionth Robot
Yulia Putintseva Calls for Spectator Ejection at Wimbledon Over Safety Concerns
House Oversight Committee Subpoenas Former Jill Biden Aide Amid Investigation into Alleged Concealment of President Biden's Cognitive Health
Amazon Reaches Major Automation Milestone with Over One Million Robots
Extreme Heat Wave Sweeps Across Europe, Hitting Record Temperatures
Meta Announces Formation of Ambitious AI Unit, Meta Superintelligence Labs
Robots Compete in Football Tournament in China Amid Injuries
China Unveils Miniature Insect-Like Surveillance Drone
Marc Marquez Claims Victory at Dutch Grand Prix Amidst Family Misfortune
Germany Votes to Suspend Family Reunification for Asylum Seekers
Budapest Pride Parade Draws 200,000 Participants Amid Government Ban
Southern Europe Experiences Extreme Heat
Xiaomi's YU7 SUV Launch Garners Record Pre-Orders Amid Market Challenges
Jeff Bezos and Lauren Sanchez's Lavish Wedding in Venice
Russia Launches Largest Air Assault on Ukraine Since Invasion
Massive Anti-Government Protests Erupt in Belgrade
Iran Executes Alleged Israeli Spies and Arrests Hundreds Amid Post-War Crackdown
Hungary's Prime Minister Criticizes NATO's Role in Ukraine
EU TO HUNGARY: LET THEM PRIDE OR PREP FOR SHADE. ORBÁN TO EU: STAY IN YOUR LANE AND FIX YOUR OWN MESS.
Hungarian Scientist to Conduct 30 Research Experiments on the International Space Station
NATO Members Agree to 5% Defense Spending Target by 2035
NATO Leaders Endorse Plan for Increased Defence Spending
U.S. Crude Oil Prices Drop Below $65 Amid Market Volatility
International Astronaut Team Launched to Space Station
Macron and Merz: Europe must arm itself in an unstable world
Germany and Italy Under Pressure to Repatriate $245bn of Gold from US Vaults
Iran Intensifies Crackdown on Alleged Mossad Operatives After Sabotage Claims
Trump Praises Iran’s ‘Very Weak’ Response After U.S. Strikes and Presses Israel to Pursue Peace
Oil Prices Set to Surge After US Strikes Iran
BA and Singapore Airlines Cancel Dubai Flights Amid Middle East Tensions
Trump Faces Backlash from MAGA Base Over Iran Strikes
Meta Bets $14 B on Alexandr Wang to Drive AI Ambitions
FedEx Founder Fred Smith, ‘Heart and Soul’ of the Company, Dies at 80
Chinese Factories Shift Away from U.S. Amid Trump‑Era Tariffs
Pimco Seizes Opportunity in Japan’s Dislocated Bond Market
Labubu Doll Drives Pop Mart to Status as China’s Most Valuable Toy Maker
Global Coal Demand Defies Paris Accord Goals
United States Conducts Precision Strikes on Iran’s Nuclear Sites
US strikes Iran nuclear sites, Trump says
×