Budapest Post

Cum Deo pro Patria et Libertate
Budapest, Europe and world news

Baby born from three people's DNA in UK first

Baby born from three people's DNA in UK first

A baby has been born using three people's DNA for the first time in the UK, the fertility regulator has confirmed.
Most of their DNA comes from their two parents and around 0.1% from a third, donor woman.

The pioneering technique is an attempt to prevent children being born with devastating mitochondrial diseases.

Up to five such babies have been born, but no further details have been released.

Mitochondrial diseases are incurable and can be fatal within days or even hours of birth. Some families have lost multiple children and this technique is seen as the only option for them to have a healthy child of their own.

Mitochondria are the tiny compartments inside nearly every cell of the body that convert food into useable energy.

Defective mitochondria fail to fuel the body and lead to brain damage, muscle wasting, heart failure and blindness.

They are passed down only by the mother. So mitochondrial donation treatment is a modified form of IVF that uses mitochondria from a healthy donor egg.

However, mitochondria have their own genetic information or DNA which means that technically the resulting children inherit DNA from their parents and a smidge from the donor as well. This is a permanent change that would be passed down through the generations.

This donor DNA is only relevant for making effective mitochondria, does not affect other traits such as appearance and does not constitute a "third parent".

The technique was pioneered in Newcastle and laws were introduced to allow the creation of such babies in the UK in 2015.

However, the UK did not immediately press ahead. The first baby born via this technique was to a Jordanian family having treatment in the US in 2016.

The Human Fertilisation and Embryology Authority (the HFEA) is saying "less than five" babies have been born as of 20 April 2023. It is not giving precise numbers to prevent the families being identified.

These limited details have emerged after a Freedom of Information request by the Guardian newspaper.

"News that a small number of babies with donated mitochondria have now been born in the UK is the next step, in what will probably remain a slow and cautious process of assessing and refining mitochondrial donation," said Sarah Norcross, the director of the Progress Educational Trust.

There has been no word from the teams in Newcastle so it is still uncertain whether the technique was successful.

Prof Robin Lovell-Badge, from the Francis Crick Research Institute, said: "It will be interesting to know how well the mitochondrial replacement therapy technique worked at a practical level, whether the babies are free of mitochondrial disease, and whether there is any risk of them developing problems later in life."

There is technically a risk of "reversion" where any defective mitochondria that are carried over could gain in number and still result in disease.

It had once been estimated that up to 150 such babies could eventually be born each year in the UK.
Newsletter

Related Articles

0:00
0:00
Close
EU Relocates Summit to Punish Hungary over Orban's Ukraine Visit
World's Hottest Day Recorded on July 21
President Biden Returns to White House After Testing COVID Negative
Thousands Protest in Mallorca Against Mass Tourism
Hacking Vulnerabilities: Androids vs. iPhones
Ukraine Crisis Should Be EU's Responsibility, Says Trump’s Envoy
Joe Biden Withdraws from 2024 US Presidential Race
A Week of Turmoil: Key Moments in US Politics
Erdogan Challenges NATO Stance at 75th Anniversary Meeting
Hungary's Orban Shakes Up EU Leadership
German National Sentenced to Death in Belarus
Elon Musk's Companies Drop CrowdStrike After Global Windows 10 Outage
Trump Pledges to End Ukraine Conflict if Reelected
Global IT Outage Unveils Digital Vulnerabilities
US Criticizes International Court's Opinion on Israeli Occupation
EU’s Patronizing Attitude Towards Africa Revealed
Ukraine to Receive First One and a Half Billion Dollars of Seized Russian Funds
Netanyahu Denounces World Court Ruling on Israeli Occupation
Massive Flight Cancellations Across the U.S. Due to Microsoft Outage
Russia Accuses Ukraine of Using Chemical Weapons
Ursula von der Leyen Wins Second Term as European Commission President
Police Officer Injured in Attack in Central Paris
Record Heat Temperatures in Ukraine Amid Power Crisis
Japan to Allocate $3.3 Billion to Ukraine Using Frozen Russian Assets
EU Parliament Condemns Hungarian PM's Russia Visit
FBI Struggles to Find Motive Behind Trump Shooting Incident
Kremlin Criticizes EU Rejection of Orban’s Ukraine Peace Proposal
Russia's Electronic Warfare Neutralizes Western Weapons in Ukraine
Trump Challenges Biden to Debate and Golf Match
Macron Accuses Israeli Minister of Election Interference
US Senator Highlights Weaknesses in Western Military Industry During Ukraine Conflict
George Clooney Urges Biden to Withdraw from Presidential Race
Political Shift in the UK: A Detailed Analysis of Labour's Victory and Future Prospects
Viktor Orbán's Peace Mission: A Diplomatic Controversy in the EU
India Advocates Peace and Prosperity: PM Modi's Speech in Austria
New UK PM Keir Starmer Reaffirms Strong Support for Ukraine at NATO Summit
Spain PM Pedro Sanchez Denounces Double Standards on Gaza at NATO Summit
Sunita Williams Safe on ISS, to Address Earth on July 10
Biden Affirms Commitment To Presidential Race
France Faces Political Turmoil and Airport Strikes Ahead of Paris Olympics 2024
Putin Hosts PM Modi for a Private Meeting
Boeing Pleads Guilty Over 737 MAX Crashes
2024 Predicted to Be World's Hottest Year
White House Denies Biden Being Treated for Parkinson's Disease
Biden to Meet New UK Prime Minister Keir Starmer
Biden Insists on Continuing Presidential Race Amid Criticism
UK Defence Minister Pledges Enhanced Support to Ukraine
French Prime Minister Gabriel Attal Resigns After Election Setback
Macron Faces New Political Challenges Despite Election Relief
France's Far-Right Falls Short in Parliamentary Elections
×